Impacts of Aluminium Chloride in Locomotion and Motor Coordination and the Protective Effects of Hippophae Salicifolia

The present study was to investigate the toxic impacts of aluminium chloride in locomotion and motor coordination in Wistar rats and to evaluate the protective effects of hydro alcoholic extract of fruit pulp of Hippophae salicifolia D. Don. (HAHS). Wistar Albino rats were assigned into four groups (n=6) and were administered respectively the vehicle, aluminium chloride 300 mg/kg (Aluminium chloride is proven to induce oxidative stress), HAHS 400 mg/kg (To check the impacts of extract on locomotion and motor co-ordination if any), aluminium chloride 300 mg/kg + HAHS 400 mg/kg respectively for 21 days (HAHS is already been proven to be effective against aluminum toxicity at the dose of 400mg/kg by combating oxidative stress). The animals were evaluated for their locomotion and motor coordination abilities using Actophotometer and Rota rod apparatus respectively. No significant toxic effects were observed on locomotion and motor coordination with chronic administration of aluminium chloride. Since the toxic impact of aluminium chloride was not prominent, HAHS has no significance in combating the impairments.