Evaluation of Hepatoprotective Effect of Cryptocoryne Spiralis against Thioacetamide Induced Acute Liver Failure

Aim of the study was to investigate the hepatoprotective effect of Cryptocoryne spiralis against thioacetamide induced acute liver failure. Male Wistar rats were used in the study. Thioacetamide induced acute liver failure model was developed by three day treatment protocol with 350 mg/kg dose i.p. Alcohol extract of C. spiralis root and rhizome (ECS) was administered p.o. at 300 mg/kg dose seven days prior to and three days post induction. Silymarin 50 mg/kg served as standard. Serum parameters ALT, AST, GGT, ALP, total proteins, total bilirubin, albumin, and ammonia were estimated prior to administration of thioacetamide followed by 24 and 48 h post administration. ECS and silymarin did not demonstrate any hepatoprotective effect rather aggravated the hepatotoxicity induced by thioacetamide as evidenced by the results of biochemical estimations and histopathology studies. Thus this study could not substantiate the claim regarding hepatoprotective effect of C.spiralis made in traditional systems of medicine.