Toxicity Study of Ethanolic Extract of Parthenium hysterophorus in Rats

LD₅₀ of ethanolic extract of Parthenium hysterophorus L. after oral administration was found to be 676.65 mg/kg body weight against rats. Tremor, convulsion, diarrhea, labored breathing, abnormal gait, food avoidance, reduced food consumption, increase in relative liver weight and decrease in body weight was observed in rats on exposure to sub lethal dosage of ethanolic extract of Parthenium hysterophorus. All the observations were found to be time and dose dependent in both male and female rats.