Photocycloaddition of Furochromenethylthiourea and Oleic Acid Methyl Ester

In the present study, photoreaction of Furochromenethylthiourea with oleic acid methyl ester (OAME) was investigated to seek information parallel to the photobiologically relevant 8-MOP-fatty acid photocycloaddition. Furochromenethylthiourea and oleic acid methyl ester were dissolved in methanol and the solution was deaerated by bubbling with nitrogen gas for about 1 hr and irradiated for 72 hr in a photochemical reactor. Progress of the reaction was monitored by thin layer chromatography (chloroform-methanol, 98:2). At the end of the reaction formation of a number of products was indicated on TLC. The two major photoproducts were isolated by eluting with dichloromethane-ethyl ether (1:1, v/v) on a silica column. The products were identified as 3 and 4 from their spectral properties.