Response of Ulcerative Disease Causing Bacterial Pathogens of Fish Channa straitus for Different Antibiotics

The current study was aimed to find out the seasonal variation of bacterial population of skin and gills of freshwater fishChanna straitus and antibiotic resistance of potential pathogens of its. Bacterial load of skin were higher than gills and mainly during summer season for total bacterial count, coliform and pathogenic bacteria. 15 potential pathogenic bacteria wereisolated as, Aeromonas sp, Bacillus sp. Escherichia coli, Shigella sp, Serratia sp, Salmonella sp. Micrococcus sp, Streptococcus, Enterococcus, Pseudomonas putida, P. aeroginosa, P. fluroscence, Staphylococcus aureus, Flavobacterium sp., which were tested for susceptibility against total twelve antibiotics, 10 individually and 4 in combination of twos. All species were resistance toamoxicillin and ampicillin. Chloramphenicol, tetracycline, streptomycin and cloxacillin were weakly effective. Ciprofloxacin, norfloxacin, azithromycin and cefixime were observed to be moderately effective. Combination antibiotics erythromycin with amoxicillin and amoxicillin with clavulanate were found to be most effective due to synergistic effect. Staphylococcus auerus, Streptococcus sp., Serratia sp., Shigella sp., Pseudomonas sp. were observed to be highly resistant. Increased antibiotics contamination of freshwater has enhanced the adaptability in pathogenic bacteria creating health risk to human being.