A 57 year old man presented with type II respiratory failure with the peripheral neuropathy and skin changes. The clinical manifestations were various, including motor symptoms (weakness), sensory symptoms (numbness), lymphadenopathy, edema, abdominal distention, and skin hyperpigmentation. Imaging studies and laboratory tests also exhibited hepatomegaly, splenomegaly, and endocrinopathy. POEMS syndrome usually manifest with peripheral neuropathy, endocrine abnormality usually diabetes mellitus, hepatomegaly and skin changes. The atypical presentations of the symptoms can be misdiagnosed as it is an extremely rare disorder. Hence a clear comprehension is necessary for identification of the case which is the key note for the researcher for enlighting the health care professionals on this disease condition.
Polyneuropathy, organomegaly, endocrinopathy, monogammopathy, cytokines
