Lower Respiratory Tract Infections place a considerable strain on the health budget and are generally more serious than Upper respirator y tract Infections. In developed countries the yearly incidence of pneumonia is estimated to be 33 per 10, 000 in children below five years and 5 to 14 per 10, 000 among children aged 0 to 16 years. Quantitative approach, pre and post test with two group research design were used. About 80 children from Government headquarters hospital and Sudha Hospital, Erode, who fulfilled the inclusion criteria were selected by simple random sampling technique, out of which 40 were group I and 40 in assigned in group II. Children between 1 month to 12 years with the signs and symptoms of Lower Respiratory Tract Infection were selected and grouped. The children were assessed before and one hour after giving salbutamol and Hypertonic Saline Nebulisation by assessing the oxygen saturation level, heart rate and respiratory pattern consecutively for three days. The result reveals that, there is significant difference in the salbutamol nebulization compared to hypertonic saline nebulization. Each nebulization has significant difference in the breathing pattern, heart rate and oxygen saturation in the post test but when compared between the two methods salbutamol is more effective than saline nebulization.