ACE Ubsertuib/deletion Polymorphism among the Bhils of Udaipur

The I/D polymorphism for ACE gene is associated with the increased risk of CVD across world populations. The present study investigated the status of this polymorphism among the Bhil population of Udaipur district, Rajasthan. DNA samples from 93 unrelated subjects were analyzed for the ACE genotype. The gene is found to be polymorphic, with allele frequencies of 0.54 and 0.46 for the I and D allele respectively. For age-wise distribution, I allele is more prevalent among the younger groups, whereas sex-wise distribution showed high frequency of I allele among males. Reduced action of ACE enzyme for II genotype as well as cultural and environmental factors may explain the genetic distribution of this polymorphism in the studied population.