1Faculty of Health and Life Sciences, Management and Science University, Seksyen 13, 40100, Shah Alam, Selangor, Malaysia Email: muhddanial_cheramli@msu.edu.my
Online published on 15 February, 2021.
Tocotrienol rich fraction [TRF] is an extraction from palm oil. The purpose of this study is to analyses the effects of TRF toward rotenone induced zebrafish. Adult zebrafish [n=60] were separated into three groups. Group 1: Normal group [n=10], Group 2: Negative group [n=10], Group 3: Experimental group [n=40]. Zebrafish [n=50] were exposed to rotenone [5ug/L] for 28 days and later separate into four different groups with different concentrations of TRF [0.15, 0.3, 1.5, 3 mL]. Adult zebrafish underwent treatment for four weeks, analyses through behaviour study and toxicity study [Lc50]. Lc50 was observed in 2.7 mL of TRF. Adult zebrafish display slow swimming pattern after inducing with rotenone, but showed significant increased after the treatment suggest that TRF notably changed the behaviour of rotenone induced zebrafish.
Parkinson's disease, Rotenone, Tocotrienol rich fraction, Danio rerio
