INTERNATIONAL JOURNAL OF MEDICAL TOXICOLOGY & LEGAL MEDICINE
  • Year: 2020
  • Volume: 23
  • Issue: 3and4

Development and evaluation of halal herbal capsule containing momordica charantia extract

  • Author:
  • Nor Syahirah Binti Shukri1, Mohammed Kaleemullah1*, Jiyauddin Khan1, Samer Al-Dhalli1, Sakina Ruhi2, Mohamed Rasny1, Shariq Baber1, Santosh Fattepur1, Kiran P. Niluga, Chean Hui Ng1, O. E. Gamal3, Ibrahim Abdullah1
  • Total Page Count: 6
  • Page Number: 29 to 34

1School of Pharmacy, Management and Science University, Seksyen 13, 40100, Shah Alam, Selangor, Malaysia

2International Medical School, Management and Science University, Seksyen 13, 40100, Shah Alam, Selangor, Malaysia

3Department of Pharmaceutics, Unaizah College

*Corresponding Author: mohd_kaleemullah@msu.edu.my

Online published on 15 February, 2021.

Abstract

Momordica charantia has been proven to have blood glucose lowering capacity similar to insulin. The aim of this study was to develop halal herbal capsule dosage form for Momordica charantia extract to mask the bitter test and investigate the suitable type of adsorbent for drying the extract. Momordica charantia was extracted and filled in capsule by using non-thermal drying method. Microcrystalline cellulose found to be the best option as pharmaceutical adsorbent for Momordica charantia extract compared to magnesium carbonate and magnesium oxide. The powder obtained with MCC has excellent flow properties with low moisture content. The capsules produced have good uniformity of weight and passed disintegration and stability test.

Keywords

Pharmaceutical adsorbents, Microcrystalline cellulose [MCC], Magnesium carbonate, Magnesium oxide, Momordica charantia