Annotation of a hypothetical Protein (A2E4V9_TRIVA) in Trichomonas vaginalis

Trichomonas vaginalis, the etiologic agent of trichomoniasis, is an anaerobic flagellated protozoan. Trichomoniasis marked by complications like preterm delivery, low birth weight, and increased mortality as well as predisposing to HIV infection, AIDS, and cervical cancer, is among the top most sexually transmitted diseases. The genome draft published in 2007 revealed many unusual genomic and biochemical features like, exceptionally large genome size of 160 Mb. Hypothetical proteins are predicted gene products that have no identifiable function assigned to them and comprise 10-60% of recognized open reading frames in annotated genomes. The analysis of hypothetical proteins provides an opportunity to search for novel drug targets and markers for treatment of Trichomoniasis, and better understanding of the large genome size of T.vaginalis. The present study shows the structural, sequential and phylogenetic analysis of a hypothetical protein of T. vaginalis A2E4V9_TRIVA, which on modeling revealed maximum alpha helices. The protein showed conserved domains of Rosemann and E2-binding superfamilies which contribute in ubiquitin mediated proteolysis and also in numerous dehydrogenases metabolic pathways such as glycolysis, and many other redox enzymes