1Department of Pharmaceutics, COP, IFTM, Moradabad-244001, Uttar Pradesh, India
2Department of Pharmaceutics, I.T, B.H.U, Varanasi221010, Uttar Pradesh, India
*Corresponding Author: Prashant Upadhyay, Email: p23upadhyay@yahoo.com
Online published on 25 April, 2013.
Solid Dispersions were prepared by solvent evaporation technique using microcrystalline cellulose, PEG 4000, PEG 6000, PVP-K30 and Gelucire 50/13. Further objective of the project was to develop fast release surface solid dispersion of glibenclamide and compressed at low pressure to form fast-melting pharmaceutical tablet. In this study, we used sodium starch glycolate for mouth dissolving nature. The inherent hygroscopic nature of PEG could decrease the affinity for moisture of effervescent mixtures and can provide a stabilizing effect. The formulations using sodium starch glycolate and surface solid dispersion with Gelucire 50/13, PEG 4000 and 6000 were found to have better release properties. Fast Release tablet of glibenclamide might aid in dissolution due to increase in microenvironmental pH around the granules and saliva.
Surface solid dispersion, Glibenclamide, PEG, Gelucire 50/13
