International Journal of Medical Toxicology & Legal Medicine
  • Year: 2022
  • Volume: 25
  • Issue: 3and4

Cytotoxic activity against human lung cancer cell line (A549) of dimethyl-tin (IV) valsartan complex

  • Author:
  • Alaa Mohammed1,*, Muataz Ali2, Wedad Al-Dahhan2, Israa Salamn3, Muna Bufaroosha4, Dheaa Zageer2, Emad Yousif
  • Total Page Count: 5
  • Page Number: 102 to 106

1Department of Medical Instrumentation Technical Engineering, Al-Hadi University College, Baghdad, 10011, Iraq

2Department of Chemistry, College of Science, Al Nahrain University, Baghdad, 64021, Iraq

3College of Science, Al Nahrain University, Baghdad, 64021, Iraq

4Department of Chemistry, College of Science, United Arab Emirates University, Al-Ain, 1818, United Arab Emirates

*Corresponding Author Dr. Alaa Mohammed, Department of Medical Instrumentation Technical Engineering, Al-Hadi University College, Baghdad, 10011, Iraq

Online published on 6 March, 2023.

Abstract

Cancer growth inhibition has been a challenge for researchers for decades. Finding suitable complexes for treatment has been a promising technique, though. Dimethyl-tin(IV) valsartan complex has been synthesized, characterized and tested as anti-cancer against A549 cell line. According to the FTIR, 1H-NMR and119Sn-NMR spectroscopy, the suggested geometry for the complex is octahedral. Me2SnL2 complex exhibit cytotoxicity for human lung cancer based on MTT assay. The achieved percentage of growth inhibition for cancer cells reach 60% at 100 µg/mL concentration.

Keywords

Tin complex, Valsartan, Biological activity, A549 cell line, MTT assay