International Journal of Medical Toxicology & Legal Medicine
  • Year: 2023
  • Volume: 26
  • Issue: 1and2

Expression of plasma mir-21 in oral squamous cell carcinoma

  • Author:
  • Santhosh Kumar Caliaperoumal1,*, Saranyan Ravi2, M. Thrumaran3, Devi Mani4, Balakrishnan Jeyakumar5
  • Total Page Count: 5
  • Page Number: 158 to 162

1Department of Dentistry, Vinayaka Missions Medical College and Hospital, Vinayaka Mission’s Research Foundation (Deemed to be University), Karaikal, Puducherry, India-609609

2Department of Periodontia, Vinayaka Mission’s Dental College & Hospital, Vinayaka Mission’s Research Foundation (Deemed to be University), Salem, Tamil Nadu, India

3Department of Dentistry, Vinayaka Missions Medical College and Hospital, Vinayaka Mission’s Research Foundation (Deemed to be University), Karaikal, Puducherry, India-609609

4Department of Oral Pathology, Adhiparasakthi Dental College and Hospital, Chennai, Tamil Nadu, India

5Central Research Laboratory Vinayaka Missions Medical College and Hospital, Vinayaka Mission’s Research Foundation (Deemed to be University), Karaikal, Puducherry

*Corresponding Author Dr. Santhosh Kumar Caliaperoumal Professor and Head Of Department Department of Dentistry, Vinayaka Missions Medical College, Vinayaka Mission’s Research Foundation (Deemed to be University), Karaikal - 609 609, Puducherry, India, E-mail: sanjosh80@gmail.com

Online Published on 28 July, 2023.

Abstract

Oral Squamous cell carcinoma is a common malignancy worldwide. MicroRNAs (miRNAs) are short, non-coding RNAs that are found to be up or downregulated in Oral cancer patients and play a role in all levels of carcinogenesis. It regulates the post-transcriptional levels of targeted mRNAs. The miRNA-21 (miR-21) is upregulated in oral carcinoma status. We studied the expression of miRNA 21 in plasma of Oral squamous cell carcinoma patients.

We observed the levels of miR21 in plasma of patients with OSCC (n 30) and healthy controls (n 30) by miRNA easy kit quagen. The fold change was observed and compared with OSCC and controls.

Plasma miR-21 levels were increased markedly in the patients with OSCC compared to controls. The patients with moderately differentiated, Stage-IV OSCC patients showed increased fold change compared to welldifferentiated and Stage-III OSCC patients.

Our results indicate that plasma miR-21 may be used as an adjuvant biomarker the detection of OSCC patient.

Keywords

Oral Squamous cell carcinoma (OSCC), Microrna-21(miRNA-21/miR-21), Microrna, Plasma