An investigation was carried out to study the effect of different rice cultivars, fertility and weed management on weed density during pre-flood environment and their subsequent effect on growth and yield in rainfed lowland, submergence-prone rice-ecosystem. Pre-emergence application of butachlor+2, 4-D (1.5+0.5 kg ha−1) followed by one hand weeding at 30 DAS and hand weeding twice (30 and 50 DAS) were most effective in minimising weed growth and enhancing rice grain yield. Grain yield was higher in fertilizer applied (40 N, 20 P, 20 K kg ha−1) treatments where weed control measures were followed as compared to no weed control measures. However, grain yield was higher where weed control measures were followed as compared to no control measure, irrespective of fertilizer applications. Cultivars Vaidehi and Barh Avrodhi recorded low weed growth and high grain yield over Madhukar.