Pre-emergence applications of thiazopyr at 240 g ha−1 significantly reduced the density and dry weight of weeds over weedy check. Whereas pre-plant incorporation of trifluralin at 1000 g ha−1 followed by glyphosate at 1025 g ha−1 or glufosinate 500 g ha−1 and paraquat 360 g ha−1 proved next best treatments and at par with each other. Significantly less per cent control Echinochloa crusgalli L. and Trianthema portulacastrum L. was noticed where trifluralin at 1000 g ha−1 was applied alone. Seed cotton yield was recorded in season long weed-free situation. Pre-emergence application of thiazopyr at 240 g ha−1 or pre-pht incorporation of trifluralin at 1000 g ha−1 and followed by other post-emergence herbicides increased the seed cotton yield significantly over weedy check. Single application of glyphosate at 1025 g ha−1 or glufosinate at 500 g ha−1 at 40 and 60 DAS increased the seed cotton yield.