A field experiment was conducted during the winter seasons of 2003–04 and 2004–05 to evaluate the effect of time of herbicides application on weeds in wheat under zero-tillage system. Herbicides applied one week after first irrigation were more effective than before first irrigation. Sulfosulfuron (25g/ha) applied after first irrigation was most effective against the grassy and broadleaf weeds and had minimum N, P and K uptake by weeds. Isoproturoon+2, 4-D sodium salt (750+500 g/ha) was at par with metribuzin (210 g/ha), but both were significantly superior to check in reducing weed growth and nutrients uptake by weeds. Sulfosulfuron had maximum number of earheads, grains/earhead, 1000-grain weight, grain yield and nutrients uptake by crop.