1Associate Professor, Department of Medicine, Institute of Medical Sciences, BHU, Varanasi, India
2Junior Resident, Department of Medicine, Institute of Medical Sciences, BHU, Varanasi, India
3Ex-Junior Resident, Department ofAnaesthesia, Indira Gandhi Institute of Medical Sciences, Patna, Varanasi, India
*Corresponding author: Dr. Anup Singh, Assistant Professor, Medicine, IMS, Banaras Hindu University, Varanasi, India. Email: dranupbhu@gmail.com
Online published on 17 June, 2017.
Macroglobulinemia refers to the excess production of IgM monoclonal protein that occurs in certain lymphoproliferative disorders and plasma cell dyscrasias. This broad definition includes patients with monoclonal gammopathy of undetermined significance of the IgM type (IgM MGUS), smoldering Waldenström macroglobulinemia (SWM), Waldenström macroglobulinemia (WM), and a number of related disorders in which an IgM monoclonal protein is detected, such as chronic lymphocytic leukemia (CLL), a number of lymphoma variants, and primary (AL) amyloidosis.
WM is a diagnosed by demonstrating lymphoplasmacytic lymphoma (LPL) in the bone marrow with an IgM monoclonal gammopathy in the blood. Infiltration of the hematopoietic tissues or the effects of monoclonal IgM in the blood causes the symptoms associated with disorder.
Macroglobulinemia, Chronic lymphocytic leukemia, Waldenström macroglobulinemia, IgM
