Disseminated Histoplasmosis Presenting as Prolonged Fever and Pancytopenia in a HIV Patient

Histoplasmosis is an opportunistic fungal infection commonly affecting immuno compromised hosts. In HIV patients it usually present as a disseminated form. We hereby report a case of Progressive Disseminated Histoplasmosis in a patient with advanced HIV infection, who presented with prolonged fever and pancytopenia. Bone marrow examination showed yeast forms of Histoplasma capsulatum. Prompt initiation of antifungal therapy and anti-retroviral therapy lead to improvement in her clinical condition. Progressive Disseminated Histoplasmosis is thus an important differential diagnosis to be considered in any HIV patient presenting with prolonged fever and pancytopenia.