Clinical experience of using acetretin in a patient of non-bullous congenital ichthyosiform erythroderma

Non-Bullous congenital ichthyosiform erythroderma (NCIE) is a rare, autosomal recessive inflammatory ichthyosis characterized by generalized scaling and erythema since birth. Associated features are ectropion, eclabion, and nail abnormalities while mental functions are normal. A patient of NCIE born out of non-consanguineous marriage presented with above described features. Patient was treated with oral acetretin 25 mg daily (~0.6mg/kg) for 4 months. Patient had marked improvement in scaling as well as Erythema without any noticeable side effects.